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Catalog Number | orb2279736 |
---|---|
Category | Small Molecules |
Description | CRT0066101 is a PRKDs inhibitor. CRT0066101 suppressed the proliferation and migration of four bladder cancer cell lines in vitro. CRT0066101 blocked tumor growth in a mouse flank xenograft model of bladder cancer. CRT0066101 treatment or PKD2 silencing arrested bladder cancer cells at the G2/M phase, the arrest being accompanied by decreases in the levels of cyclin B1, CDK1 and phospho-CDK1 (Thr161) and increases in the levels of p27Kip1 and phospho-CDK1 (Thr14/Tyr15). CRT0066101 suppresses bladder cancer growth by inhibiting PKD2 through induction of G2/M cell cycle arrest, leading to the blockade of cell cycle progression. |
CAS Number | [956121-30-5] |
MW | 342.8226626 |
SMILES | C1(O)=CC=C(Cl)C=C1C1=NC(NC[C@H](N)CC)=C2C(=N1)C=CC=C2 |
Formula | C18H19CLN4O |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
[1290629-45-6] | |
447.8 | |
C18H22N6O.3HCl |
> 98% (HPLC) | |
956121-30-5 |
> 98% (HPLC) | |
2308510-39-4 |
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