CRT0066101 hydrochloride

• Catalog Number: orb2283813
• Category: Small Molecules
• Description: CRT0066101 hydrochloride
• CAS Number: 1781742-22-0
• MW: 374.87
• SMILES: Cl.CC[C@@H](N)CNc1ccnc(n1)-c1cc(ccc1O)-c1cnn(C)c1
• Formula: C₁₈H₂₃ClN₆O
• Biological Activity: Protein kinase D (PKD), a serine/threonine protein kinase activated by diacylglycerol downstream of PKC signaling, has three human isoforms that modulate cell proliferation, survival, invasion, and protein transport. CRT0066101 acts as an inhibitor of these three PKD isoforms, with IC50 values of 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively. It demonstrates selectivity for PKD over a range of more than 90 protein kinases, including PKCα, PKBα, MEK, ERK, c-Raf, c-Src, and c-Abl. This specificity allows CRT0066101 to inhibit cell proliferation, induce apoptosis, and notably reduce the viability of pancreatic cancer cells both in vitro and in vivo.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.