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CRANAD-2
Catalog Number: orb746364
| Catalog Number | orb746364 |
|---|---|
| Category | Small Molecules |
| Description | CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Moreover, this probe also shows a high affinity for Abeta aggregates (K(d) = 38.0 nM), a reasonable log P value (log P = 3), considerable stability in serum, and a weak interaction with albumin. After intravenous injection of this probe, 19-month-old Tg2576 mice exhibited significantly higher relative signal than that of the control mice over the same period of time. |
| CAS Number | [1193447-34-5] |
| MW | 410.264612913132 |
| SMILES | CN(C)C1=CC=C(C=C1)\C=C/C2O[B-](F)(F)O\C(=C/C=C3C=CC(=[N+](C)C)C=C3)C=2 |
| Formula | C23H25BF2N2O2 |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
CRANAD 2 [orb1305847]
98.53%
1193447-34-5
410.27
C23H25BF2N2O2
50 mg, 200 mg, 2 mg, 100 mg, 25 mg, 10 mg, 5 mg
