CRANAD-2

• Catalog Number: orb746364
• Category: Small Molecules
• Description: CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Moreover, this probe also shows a high affinity for Abeta aggregates (K(d) = 38.0 nM), a reasonable log P value (log P = 3), considerable stability in serum, and a weak interaction with albumin. After intravenous injection of this probe, 19-month-old Tg2576 mice exhibited significantly higher relative signal than that of the control mice over the same period of time.
• CAS Number: [1193447-34-5]
• MW: 410.2646129
• SMILES: CN(C)C1=CC=C(C=C1)\C=C/C2O[B-](F)(F)O\C(=C/C=C3C=CC(=[N+](C)C)C=C3)C=2
• Formula: C₂₃H₂₅BF₂N₂O₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.