Corylifol A

• Catalog Number: orb1302369
• Category: Small Molecules
• Description: Corylifol A
• CAS Number: 775351-88-7
• Purity: 99.48%
• MW: 390.47
• SMILES: CC(C)=CCC\C(C)=C\Cc1cc(ccc1O)-c1coc2cc(O)ccc2c1=O
• Formula: C₂₅H₂₆O₄
• Biological Activity: 1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potential uncouplers of neuronal nitric oxide synthase-postsynaptic density protein-95. 3. Corylifol A and bavachin are strong inhibitors of UDP-glucuronosyltransferase 1A1 (UGT1A1) with the inhibition kinetic parameters (Ki) values lower than 1 uM.4. Corylifol A and bakuchiol are naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62uM to 3.89 uM. 5. Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 0.81 ± 0.15 uμ, it also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells, suggests that corylifol A has antiinflammatory activity.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.