COL-144 (Lasmiditan) succinate

SKU: orb746438

Description

Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study. Lasmiditan showed efficacy in its primary endpoint, with a 2-hour placebo-subtracted headache response of 28.8%, though with frequent reports of dizziness, paresthesias, and vertigo.

Key Properties

• CAS Number: 439239-92-6
• MW: 872.808711528778
• Purity: >98%
• Formula: C₄₂H₄₂F₆N₆O₈
• SMILES: FC1C=C(C=C(C=1C(NC1=CC=CC(C(C2CCN(C)CC2)=O)=N1)=O)F)F.FC1C=C(C=C(C=1C(NC1=CC=CC(C(C2CCN(C)CC2)=O)=N1)=O)F)F.OC(CCC(=O)O)=O

Storage & Handling

• Disclaimer: For research use only