COG 133

• Catalog Number: orb654723
• Category: Small Molecules
• Description: COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM[1][2].Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into the spinal cord. Also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors (IC50 = 445 nM).
• CAS Number: [514200-66-9]
• MW: 2283.78
• SMILES: [Ac-LRVRLASHLRKLRKRLL-NH2]
• Formula: C₉₉H₁₈₂F₃N₃₇O₂₁
• Note: For research use only
• Expiration Date: 12 months from date of receipt.