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CNTF Protein, Human, Recombinant
Catalog Number: orb1962135
| Catalog Number | orb1962135 |
|---|---|
| Category | Proteins |
| Description | Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83% homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown. |
| Tag | Tag Free |
| Purity | 98.00% |
| MW | 25 KDa (reducing condition) |
| UniProt ID | P26441 |
| Protein Sequence | Ala2-Met200 |
| Expression System | E. coli |
| Biological Origin | Human |
| Biological Activity | Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83% homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown. |
| Expression Region | Ala2-Met200 |
| Storage | -20°C |
| Note | For research use only |
| Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Expiration Date | 6 months from date of receipt. |
- Item 1 of 1
Human CNTF protein (Active) [orb359177]
> 97% as determined by SDS-PAGE and HPLC.
22.9 kDa
E.Coli
5 μg, 100 μg, 500 μg - Item 1 of 1
- Item 1 of 1
Human CNTF Protein [orb1471705]
Greater than 95% as determined by reducing SDS-PAGE.
22.93 KDa
Mammalian
50 μg, 10 μg Human CNTF protein [orb603982]
Greater than 90% as determined by SDS-PAGE.
26.1 kDa
E.coli
20 μg, 100 μg, 1 mgHuman CNTF protein [orb594966]
Greater than 85% as determined by SDS-PAGE.
26.8 kDa
Baculovirus
20 μg, 100 μg, 1 mg
