CLP-290

• Catalog Number: orb654670
• Category: Small Molecules
• Description: CLP290 (CLP-290) is an orally acirtve small molecule K+-Cl- cotransporter isotype 2 (KCC2) activator, the carbamate prodrug of CLP257; In vivo co-treatment with morphine and oral CLP290 prevented membrane KCC2 downregulation in SDH neurons. Concurrently, co-treatment with CLP290 significantly mitigated MIH and acute administration of CLP257 in established MIH restored normal nociceptive behavior.
• CAS Number: [1181083-81-7]
• MW: 404.46
• SMILES: N(C(OC1=CC(F)=CC=C1/C=C1\SC(N2NCCCC2)=NC\1=O)=O)1CCCC1
• Formula: C₁₉H₂₁FN₄O₃S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.