Clopidogrel Carboxylic Acid (hydrochloride)

• Catalog Number: orb1694026
• Category: Small Molecules
• Description: Clopidogrel Carboxylic Acid (hydrochloride)
• CAS Number: 144750-42-5
• Purity: 98%
• MW: 344.26
• SMILES: [C@H](C(O)=O)(N1CC2=C(CC1)SC=C2)C3=C(Cl)C=CC=C3.Cl
• Formula: C₁₅H₁₅Cl₂NO₂S
• Biological Activity: Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active thiol metabolite via CYP2C19 in the liver enables its anti-aggregating activity. An estimated 15% of administered clopidogrel is metabolized by CYP2C19 to the thiol metabolite. Clopidogrel carboxylic acid is a major inactive metabolite of clopidogrel. Most (85%) of circulating clopidogrel is hydrolyzed by esterases to this carboxylic acid form. This inactive metabolite can be used as a reference standard for quantitative analysis of clopidogrel metabolism.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.