Claudin-4 Protein-VLP, Human, Recombinant

• Catalog Number: orb1960192
• Category: Proteins
• Description: Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.
• Purity: 98.00%
• MW: 23.31 kDa (predicted)
• UniProt ID: O14493
• Expression System: HEK293 Cells
• Biological Origin: Human
• Biological Activity: Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.
• Expression Region: Met1-Val209
• Storage: -20°C
• Note: For research use only
• Expiration Date: 6 months from date of receipt.