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Cl-amidine hydrochloride
Catalog Number: orb1309827
| Catalog Number | orb1309827 |
|---|---|
| Category | Small Molecules |
| Description | Cl-amidine hydrochloride |
| CAS Number | 1373232-26-8 |
| Purity | 98.14% |
| MW | 347.24 |
| SMILES | Cl.NC(=O)[C@H](CCCNC(=N)CCl)NC(=O)c1ccccc1 |
| Formula | C14H20Cl2N4O2 |
| Biological Activity | Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro causing cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation. It improves survival in a murine sepsis model. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
