cis-ISRIB

• Catalog Number: orb2279733
• Category: Small Molecules
• Description: cis-ISRIB is a weak inhibitor of PERK signaling compared to trans-ISRIB , potently reverses the effects of eIF2α phosphorylation with IC50 of 600 nM.ISRIB reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress, displays significant enhancement in spatial and fear-associated learning.ISRIB is a potent inhibitor of the integrated stress response (ISR)integrated stress response (ISR).
• CAS Number: [548470-11-7]
• MW: 451.343
• SMILES: ClC1C([H])=C([H])C(=C([H])C=1[H])OC([H])([H])C(N([H])C1([H])C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])N([H])C(C([H])([H])OC1C([H])=C([H])C(=C([H])C=1[H])Cl)=O)=O
• Formula: C₂₂H₂₄CL₂N₂O₄
• Note: For research use only
• Expiration Date: 12 months from date of receipt.