Cinobufagin (Cinobufagine)

• Catalog Number: orb746390
• Category: Small Molecules
• Description: Cinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti-liver cancer. IC50 value: Target: In vitro: Cinobufagin inhibited proliferation of cancer cells at doses of 0.1, 1, or 10 μM after 2–4 days of culture. Cytotoxicity of cinobufagin on the DU145 and LNCaP cells was dose-dependent. Cinobufagin increased [Ca2+]i and apoptosis in cancer cells after a 24-hr culture as well as caspase 3 activities in DU145 and PC3 cells and caspase 9 activities in LNCaP cells [1]. Cinobufagin suppresses cell proliferation and causees apoptosis in prostate cancer cells via a sequence of apoptotic modulators, including Bax, cytochrome c and caspases [2].
• CAS Number: [470-37-1]
• MW: 442.55
• SMILES: C[C@]([C@H]1C(C=C2)=COC2=O)(CC3)[C@]([C@@]4([H])[C@@]3([H])[C@](CC[C@H](O)C5)(C)[C@]5([H])CC4)(O6)[C@H]6[C@@H]1OC(C)=O
• Formula: C₂₆H₃₄O₆
• Note: For research use only
• Expiration Date: 12 months from date of receipt.