CID 139600315(GNF-4877)

• Catalog Number: orb691946
• Category: Small Molecules
• Description: GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6?nM and 16?nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66?μM for mouse β (R7T1) cells)[1].
• CAS Number: [2041073-22-5]
• MW: 494.5180886
• SMILES: FC1C=CC(=CC=1C1=CN=C(C(C(NC2C=NC=CC=2N2CCC[C@@H](C(=O)O)C2)=O)=N1)N)OC(C)C
• Formula: C₂₅H₂₇FN₆O₄
• Note: For research use only
• Expiration Date: 12 months from date of receipt.