Cibinetide

• Catalog Number: orb1821035
• Category: Proteins
• Description: Erythropoietin/CD131 heteroreceptor agonist; Peptides.
• CAS Number: 1208243-50-8
• Modifications: X is pyroglutamic acid.
• Structure: Glp-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH (Glp is pyroglutamic acid)
• Target Areas: Cytokine receptors
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 1257.31 Da
• Formula: C₅₁H₈₄N₁₆O₂₁
• Solubility (25°C): > 50 mg per ml in water
• Protein Sequence: XEQLERALNSS
• Storage: Store dry, frozen and in the dark
• Alternative names: ARA 290, Pyroglutamate Helix B Surface Peptide, pH
• Background: Cibinetide is a linear nonhematopoietic peptide that mimics the three-dimensional structure of the helix B surface domain of erythropoietin (EPO). Cibinetide binds selectively to the non-hematopoietic EPO receptor (the innate repair receptor, IRR), which is a heterodimer of the EPO receptor and the cytokine family beta common receptor (βCR, CD131). The IRR becomes locally upregulated following tissue injury and its activation initiates a local anti-inflammatory response, inhibition of death signal and anti-apoptosis, preventing overt tissue damage. Cibinetide produces effective and long-term pain relief following peripheral nerve damage, an effect mediated by its anti-inflammatory and immunomodulatory functions, and the IRR is thought to be a point of integration between the immune system and pain signalling via nociception. Cibinetide possesses analgesic and tissue protective effects in many diseases such as diabetes and cancer.
• Note: For research use only
• Expiration Date: 6 months from date of receipt.