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Catalog Number | orb613915 |
---|---|
Category | Antibodies |
Description | Human monoclonal antibody to CD80 |
Species/Host | Human |
Clonality | Monoclonal |
Clone Number | IDEC-114 (Galiximab) |
Tested applications | Blocking, ELISA, FC, IHC, IP, WB |
Reactivity | Human |
Isotype | IgG1 |
Immunogen | Galiximab was prepared by immunizing cynomolgus monkeys with recombinant CD80 antigen. The variable regions of the light and heavy chains were then cloned by being incorporated into a cassette vector (N5LG1) containing human constant region genes and subsequently transfected into the Dg44 CHO cell line (Hariharan K, 2013) |
Concentration | 1 mg/ml |
Purity | Purified |
Conjugation | Unconjugated |
Target | CD80 |
UniProt ID | P33681 |
Storage | Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. |
Buffer/Preservatives | PBS with 0.02% Proclin 300. |
Alternative names | B7-1; T-lymphocyte activation antigen CD80; Activa Read more... |
Note | For research use only |
Application notes | Galiximab acts to decrease in cell proliferation, inhibition of the constitutively active NF-κB pathway, increase in apoptosis and ADCC against various B-cell lymphoma cell lines. Galiximb affects CD28 and CD152 interactions with CD80. This antibody can also be used for FC, WB, ELISA, IP and IHC. |
Expiration Date | 12 months from date of receipt. |
ELISA, FACS, IF, IHC-P, WB | |
Human | |
Mouse | |
Monoclonal | |
Unconjugated |
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