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    CD63 Antibody / LAMP-3

    Catalog Number: orb640065

    DispatchUsually dispatched within 5-10 working days
    $ 764.00
    Catalog Numberorb640065
    CategoryAntibodies
    DescriptionThis MAb recognizes protein of 26kDa-60kDa, which is identified as CD63. Its epitope is different from that of MAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
    Species/HostMouse
    ClonalityMonoclonal
    Clone NumberLAMP3/2789
    Tested applicationsIHC-P, WB
    ReactivityHuman, Mouse
    IsotypeMouse IgG2b, kappa
    ImmunogenA recombinant human partial protein (amino acids 100-197) was used as the immunogen for the CD63 antibody.
    Dilution rangeWestern blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml
    PurityProtein G affinity chromatography
    ConjugationUnconjugated
    Formula0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
    Hazard InformationThis CD63 antibody is available for research use only.
    UniProt IDP08962
    StorageStore the CD63 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
    Buffer/Preservatives0.2 mg/ml with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide
    NoteFor research use only
    Application notesOptimal dilution of the antibody should be determined by the researcher.
    Expiration Date12 months from date of receipt.
    CD63 Antibody / LAMP-3

    IHC staining of FFPE human melanoma with CD63 antibody (clone LAMP3/2789). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

    CD63 Antibody / LAMP-3

    IHC staining of FFPE human melanoma with CD63 antibody (clone LAMP3/2789). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

    CD63 Antibody / LAMP-3

    Western blot testing of human spleen lysate with CD63 antibody (clone LAMP3/2789). Predicted molecular weight: 25-60 kDa depending on glycosylation level.

    CD63 Antibody / LAMP-3

    Analysis of HuProt (TM) microarray containing more than 19000 full-length human proteins using CD63 antibody (clone LAMP3/2789). These results demonstrate the foremost specificity of the LAMP3/2789 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

    CD63 Antibody / LAMP-3

    SDS-PAGE analysis of purified, BSA-free CD63 antibody (clone LAMP3/2789) as confirmation of integrity and purity.

    • CD63 Antibody / LAMP-3 [orb749338]

      FACS,  IF,  IHC-P,  WB

      Human, Mouse

      Mouse

      Monoclonal

      Unconjugated

      100 μg, 20 μg
    • CD63 Antibody / LAMP-3 [orb749335]

      FACS,  IF,  IHC-P

      Human, Mouse

      Mouse

      Monoclonal

      Unconjugated

      100 μg, 20 μg
    • CD63 Antibody / LAMP-3 [orb749918]

      FACS,  IHC-P

      Human

      Mouse

      Monoclonal

      Unconjugated

      100 μg, 20 μg
    • CD63 Antibody / LAMP-3 [orb699536]

      IHC-P

      Human

      Mouse

      Monoclonal

      Unconjugated

      20 μg, 100 μg
    • CD63 Antibody / LAMP-3 [orb640058]

      IHC-P,  WB

      Human

      Mouse

      Monoclonal

      Unconjugated

      100 μg, 20 μg
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