CCT-367766

• Catalog Number: orb692099
• Category: Small Molecules
• Description: CCT367766 is a potent and the third generation heterobifunctional and PROTAC-based pirin targeting protein degradation probe (PDP), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein[1].
• CAS Number: [2229856-58-8]
• MW: 946.41
• SMILES: N1C2C(=CC(C(NC3=CC(NC(C4=CC=C5C(=C4)OCCO5)=O)=CC=C3Cl)=O)=CC=2)C=CC=1CN1CCN(CCOCCOCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1
• Formula: C₄₉H₄₈ClN₇O₁₁
• Note: For research use only
• Expiration Date: 12 months from date of receipt.