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Catalog Number | orb613910 |
---|---|
Category | Antibodies |
Description | Rabbit monoclonal antibody to CCR4 |
Species/Host | Human |
Clonality | Monoclonal |
Clone Number | KW-0761 (Mogamulizumab) |
Tested applications | Depletion |
Reactivity | Human |
Isotype | IgG |
Immunogen | This antibody was prepared by humanization of a mouse anti-CCR4 mAb. |
Concentration | 1 mg/ml |
Purity | Purified |
Conjugation | Unconjugated |
Target | CCR4 |
UniProt ID | P51679 |
Storage | Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. |
Buffer/Preservatives | PBS with 0.02% Proclin 300. |
Alternative names | CD194; CKR-4; CCR-4; CCR4; K5-5 Read more... |
Note | For research use only |
Application notes | The clinically used format of this antibody (which underwent additional de-fucosylation to increase antibody-dependent cellular cytotoxicity (ADCC)), has significant clinical activity in heavily pretreated patients with mycosis fungoides and Sézary syndrome, and is associated with an overall response rate of 36.8% and a median duration of response of 10.4 months (Duvic et al, 2014). It was shown to CCR4-expressing cells by antibody-dependent, cell-mediated cytotoxicity (ADCC). Therapeutically, this results in a dual mechanism of action; in addition to directly targeting malignant T cells over-expressing CCR4, this antibody also depletes T reg cells, an important therapeutic target in human cancers. This antibody is well-tolerated, and administration does not appear to trigger clinically significant autoimmune complications in phase 1/2 trials (Duvic et al, 2014). This antibody has been approved in Japan for the treatment of relapsed or refractory adult T-cell leukemia/lymphoma, and is in clinical trials for solid cancers. For the avoidance of doubt - the material produced by Biorbyt has not been de-fucosylated. |
Expiration Date | 12 months from date of receipt. |
ELISA, IHC-P, WB | |
Human, Mouse, Rat | |
Rabbit | |
Polyclonal | |
Unconjugated |
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