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CCL16 Protein, Human, Recombinant
Catalog Number: orb1962193
| Catalog Number | orb1962193 |
|---|---|
| Category | Proteins |
| Description | CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC chemokines, showing less than 30% sequence identity. CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8. Recombinant CCL16 has been shown to chemoattract human monocytes and THP1 cells but not resting lymphocytes nor neutrophils. CCL16 has potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. CCL16ninduces a calcium flux in THP1 cells that can be desensitized by prior exposure to RANTES, suggesting that CCL16 and RANTES share the same receptor in THP1 cells. |
| Tag | Tag Free |
| Purity | 98.00% |
| MW | 14 KDa (reducing condition) |
| UniProt ID | O15467 |
| Protein Sequence | Gln24-Gln120 |
| Expression System | E. coli |
| Biological Origin | Human |
| Biological Activity | CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC chemokines, showing less than 30% sequence identity. CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8. Recombinant CCL16 has been shown to chemoattract human monocytes and THP1 cells but not resting lymphocytes nor neutrophils. CCL16 has potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. CCL16ninduces a calcium flux in THP1 cells that can be desensitized by prior exposure to RANTES, suggesting that CCL16 and RANTES share the same receptor in THP1 cells. |
| Expression Region | Gln24-Gln120 |
| Storage | -20°C |
| Note | For research use only |
| Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Expiration Date | 6 months from date of receipt. |
- Item 1 of 1
Human CCL16 protein (Active) [orb359044]
> 97% as determined by SDS-PAGE and HPLC.
11.2 kDa
E.Coli
500 μg, 5 μg, 100 μg - Item 1 of 1
Human CCL16 protein [orb244076]
Greater than 90% as determined by SDS-PAGE.
27.2 kDa
E.coli
20 μg, 100 μg, 1 mg - Item 1 of 1
Human CCL16 Protein [orb1471709]
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
11 KDa
Mammalian
50 μg, 10 μg Human CCL16 protein [orb391362]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
E. coli
500 μg, 50 μg, 10 μgRecombinant Human C-C motif chemokine 16 protein(CCL16) (Active) [orb1650819]
5 μg, 20 μg, 100 μg, 250 μg, 1 mg, 500 μg
