CC-90011 besylate

• Catalog Number: orb654729
• Category: Small Molecules
• Description: CC-90011 is a potent and orally active LSD1 inhibitor. CC-90011 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4, respectively. CC-90011 exhibits potent on-target induction of cellular differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cell lines, and antitumor efficacy in patient-derived xenograft (PDX) SCLC models.
• CAS Number: [2097523-60-7]
• MW: 609.6488
• SMILES: N#CC1=CC=C(C(N=C(N2CCC(N)CC2)N3)=C(C4=CC=C(OC)C(F)=C4)C3=O)C=C1F.O=S(C5=CC=CC=C5)(O)=O
• Formula: C₃₀H₂₉F₂N₅O₅S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.