CC-90009

• Catalog Number: orb1089598
• Category: Small Molecules
• Description: CC-90009 is a cereblon modulator. CC-90009 specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex. This leads to the ubiquitination of certain substrate proteins and induces the proteasome-mediated degradation of certain transcription factors, including Ikaros (IKZF1) and Aiolos (IKZF3), which are transcriptional repressors in T-cells. This reduces the levels of these transcription factors, and modulates the activity of the immune system, which may include the activation of T-lymphocytes. .
• CAS Number: [1860875-51-9]
• MW: 461.8458314
• SMILES: ClC1C=CC(=CC=1)C(C(NCC1C=CC2C(N(CC=2C=1)C1C(NC(CC1)=O)=O)=O)=O)(F)F
• Formula: C₂₂H₁₈CLF₂N₃O₄
• Note: For research use only
• Expiration Date: 12 months from date of receipt.