CBR-5884

• Catalog Number: orb1308487
• Category: Small Molecules
• Description: CBR-5884
• CAS Number: 681159-27-3
• Purity: 100%
• MW: 336.39
• SMILES: CCOC(=O)C1=C(C)C(SC#N)=C(NC(=O)C2=CC=CO2)S1
• Formula: C₁₄H₁₂N₂O₄S₂
• Biological Activity: CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.