Capmatinib hydrochloride

• Catalog Number: orb1089428
• Category: Small Molecules
• Description: Capmatinib, also known as INCB28060 and INC280, is an orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor INC280 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. Capmatinib was approved in 2020.
• CAS Number: [1865733-40-9]
• MW: 503.3562458
• SMILES: FC1=C(C(NC)=O)C=CC(=C1)C1C=NC2=NC=C(CC3C=CC4=C(C=CC=N4)C=3)N2N=1.Cl.Cl.O
• Formula: C₂₃H₂₁CL₂FN₆O₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.