Branaplam hydrochloride

• Catalog Number: orb1908994
• Category: Small Molecules
• Description: Branaplam hydrochloride
• CAS Number: 1562338-39-9
• MW: 429.95
• SMILES: Cl.CC1(C)CC(CC(C)(C)N1)Oc1ccc(nn1)-c1ccc(cc1O)-c1cn[nH]c1
• Formula: C₂₂H₂₈ClN₅O₂
• Biological Activity: Branaplam (LMI070; NVS-SM1) hydrochloride is a selective, orally active SMN2 splicing modulator that acts on SMN (EC50: 20 nM). branaplam hydrochloride inhibits hERG (IC50: 6.3 μM). In a mouse model of severe spinal muscular atrophy (SMA), Branaplam hydrochloride increased full-length SMN protein and improved survival.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.