Bragsin2

• Catalog Number: orb1308526
• Category: Small Molecules
• Description: Bragsin2
• CAS Number: 342795-08-8
• Purity: 98.47%
• MW: 289.16
• SMILES: COc1ccc2oc(cc(=O)c2c1[N+]([O-])=O)C(F)(F)F
• Formula: C₁₁H₆F₃NO₅
• Biological Activity: Bragsin2 (6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one) is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2 that inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin2 binds at the interface between the pleckstrin homology domain of BRAG2 and the lipid bilayer, leading BRAG2 unable to activate lipidated Arf GTPase.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.