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Bractoppin
Catalog Number: orb746313
| Catalog Number | orb746313 |
|---|---|
| Category | Small Molecules |
| Description | Bractoppin is a potent, small-molecule chemical inhibitor that specific selectively blocks phosphopeptide recognition by the BRCA1 tBRCT domain with binding IC50 of 74 nM; shows no inhibition for recognition of cognate biotinylated phosphopeptides to the TOPBP1 tBRCT 7/8, or GRB2 SH2 proteins; engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket; inhibits substrate recognition detected by F?rster resonance energy transfer, and diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51; selectively interrupts BRCA1 tBRCT-dependent signals evoked by DNA damage. |
| CAS Number | [2290527-07-8] |
| MW | 414.474 |
| SMILES | O=C(C1C=C2C(NC(=N2)C2C=CC=CC=2)=CC=1)N1CCN(CC2C(F)=CC=CC=2)CC1 |
| Formula | C25H23FN4O |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
Bractoppin [orb1218378]
> 98% (HPLC)
2290527-07-8
50 mg, 100 mg, 5 mg, 10 mg, 25 mg, 1 g, 500 mg, 200 mg, 2 mgBractoppin [orb1298563]
99.65%
2290527-07-8
414.47
C25H23FN4O
5 mg, 10 mg, 25 mg, 100 mg, 50 mg, 1 mL*10mM (in DMSO), 1 mg, 500 mg
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