Bractoppin

• Catalog Number: orb1298563
• Category: Small Molecules
• Description: Bractoppin
• CAS Number: 2290527-07-8
• Purity: 99.65%
• MW: 414.47
• SMILES: C(=O)(C=1C=C2C(N=C(N2)C3=CC=CC=C3)=CC1)N4CCN(CC5=C(F)C=CC=C5)CC4
• Formula: C₂₅H₂₃FN₄O
• Biological Activity: Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.