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BO-264
Catalog Number: orb654570
| Catalog Number | orb654570 |
|---|---|
| Category | Small Molecules |
| Description | BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity[1]. |
| CAS Number | [2408648-20-2] |
| MW | 353.37 |
| SMILES | COC1C=CC(C2C=C(NC3C=CN=C(N4CCOCC4)N=3)ON=2)=CC=1 |
| Formula | C18H19N5O3 |
| Hazard Information | Non-Toxic |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
