BMY-14802 hydrochloride

SKU: orb1704654

Description

BMY-14802 hydrochloride

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 105565-55-7
• MW: 384.85
• Purity: 99.97%
• Formula: C₁₈H₂₃ClF₂N₄O
• SMILES: Cl.OC(CCCN1CCN(CC1)c1ncc(F)cn1)c1ccc(F)cc1
• Target: 5-HT Receptor,Adrenergic Receptor,Sigma receptor
• Solubility: H2O:9 mg/mL (23.39 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.2 mM)

Bioactivity

• Target IC50:
  σ receptor:112 nM IC50
• In Vivo:
  Intraperitoneal administration of BMY-14802 hydrochloride (5-20 mg/kg) shows anti-dyskinetic efficacy across a 4-fold dose range against L-DOPA-induced dyskinesias without affectin the efficacy of L-DOPA against lesion-induced akinesia. BMY-14802 hydrochloride reduces D1 and D2 receptor agonist-induced dyskinesia.
• In Vitro:
  BMY-14802 hydrochloride shows effects o the firing of 5 hTergic and catecholaminergic neurons and affects behaviors in a 5 hT1A-sensitive manne.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

BMS181100 Hydrochloride, BMS-181100 Hydrochloride, BMS 181100 Hydrochloride, BMS 181100 hydrochloride, BMY14802 Hydrochloride, BMY-14802 Hydrochloride, BMY-14802-1, BMY 14802 hydrochloride, BMY 14802 Hydrochloride, 5HT Receptor, 5-HT1A, AdrenergicReceptor, Adrenergic Receptor, 5HTReceptor, Sigma receptor, Sigmareceptor, α1-adrenergic receptor, σ

Compound Identifiers

PubChem CID

3086514