BMS-986313

• Catalog Number: orb1910405
• Category: Small Molecules
• Description: BMS-986313 is a potent, selective, orally active RORγt inverse agonist with EC50 of 3.6 nM in GAL-4 reporter assay in Jurkat cell line, and 50 nM in IL-17 human whole blood assay.BMS-986313 demonstrated robust efficacy in preclinical models of psoriasis (the IMQ-induced skin lesion model and the IL-23-induced acanthosis model).
• MW: 498.92
• SMILES: O=C1C(C2=NN=C(CC3=NC=C(Cl)C=C3)O2)=C(O)C(C4=C(OC)C=CC=C4OC)=C(COCC)N1
• Formula: C₂₄H₂₃ClN₄O₆
• Note: For research use only
• Expiration Date: 12 months from date of receipt.