BMS-986251

• Catalog Number: orb1910826
• Category: Small Molecules
• Description: BMS-986251 is an orally active and selective RORγt inverse agonist with an EC50 of 12 nM for RORγt GAL4. BMS-986251 inhibits IL-17 with an EC50 of 24 nM in human whole blood assay. BMS-986251 demonstrates robust efficacy in mouse acanthosis and Imiquimod-induced models (preclinical models of psoriasis).
• CAS Number: [2460133-35-9]
• MW: 667.6072
• SMILES: [C@H]1([C@H](C(=O)N2[C@@]3(CCC4=CC(C(C(F)(F)F)(F)C(F)(F)F)=CC=C4[C@]3(S(=O)(=O)C3C=CC(F)=CC=3)CC2)[H])CC[C@@H](C(=O)O[H])C1)C
• Formula: C₃₀NO₅F₈SH₂₉
• Note: For research use only
• Expiration Date: 12 months from date of receipt.