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BMS-754807
Catalog Number: orb322221
| Catalog Number | orb322221 |
|---|---|
| Category | Small Molecules |
| Description | BMS-754807 is an inhibitor of the insulin receptor (InsR) and IGF-1R that exhibits anticancer chemotherapeutic activity. BMS-754807 enhances the efficacy of other co-administered chemotherapeutics, decreasing levels of activated Akt, increasing cleavage of PARP and caspase 3, and inhibiting proliferation in pancreatic ductal adenocarcinoma cells and breast cancer cells in vitro and growth of tumor xenografts in vivo. |
| CAS Number | 1001350-96-4 |
| Purity | ≥99% |
| MW | 461.51 |
| SMILES | C[C@]1(CCCN1c2nc(c3cccn3n2)Nc4cc([nH]n4)C5CC5)C(=O)Nc6ccc(nc6)F |
| Formula | C23H26FN9O |
| Chemical Name | (2S)-1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide |
| Hazard Information | UN Number: Not dangerous goods |
| Solubility (25°C) | DMSO 92 mg/mL (199.35 mM) Ethanol 92 mg/mL (199.35 mM) Water Insoluble |
| Storage | Storage Temp: -20°C |
| Alternative names | BMS754807 Read more... |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
Chemical structure of BMS-754807
- Item 1 of 1
BMS-754807 [orb1305620]
98.86%
1001350-96-4
461.49
C23H24FN9O
5 mg, 10 mg, 2 mg, 25 mg, 50 mg, 100 mg, 1 mg, 1 ml x 10 mm (in DMSO)
