BMS-599626 Hydrochloride

• Catalog Number: orb1689893
• Category: Small Molecules
• Description: BMS-599626 Hydrochloride
• CAS Number: 873837-23-1
• Purity: 98%
• MW: 567.01
• SMILES: N(C=1C=2N(C=C(NC(OC[C@@H]3COCCN3)=O)C2C)N=CN1)C=4C=C5C(=CC4)N(CC6=CC(F)=CC=C6)N=C5.Cl
• Formula: C₂₇H₂₈ClFN₈O₃
• Biological Activity: BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable inhibitor of HER1 and HER2, with IC 50 s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride shows ~8-fold less potent to HER4 (IC 50 =190 nM), > 100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy [1] [2].
• Note: For research use only
• Expiration Date: 12 months from date of receipt.