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BI-3663
Catalog Number: orb1988674
| Catalog Number | orb1988674 |
|---|---|
| Category | Small Molecules |
| Description | BI-3663 is a highly selective PTK2/FAK PROTAC that utilizes cereblon ligands to hijack E3 ligases for PTK2 degradation, with an IC50 of 18 nM. It is composed of BI-4464 linked to Pomalidomide with a linker[1]. Anti-cancer. |
| CAS Number | 2341740-84-7 |
| Purity | 98.00% |
| MW | 917.84 |
| SMILES | O=C(NCCOCCOCCOCCC(=O)NC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C(NC5=NC=C(C(=N5)OC6=CC=CC7=C6C(=O)CC7)C(F)(F)F)C(OC)=C4 |
| Formula | C44H42F3N7O12 |
| Biological Activity | BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 linked to Pomalidomide with a linker[1]. Anti-cancer activity[1]. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
