BI-2852

• Catalog Number: orb654527
• Category: Small Molecules
• Description: BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based drug design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) because it binds to a different pocket present in both the active and inactive forms of KRAS. BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells[1].
• CAS Number: [2375482-51-0]
• MW: 516.59
• SMILES: O=C1C2C([H])=C([H])C(=C([H])C=2[C@@]([H])(C2C3=C([H])C([H])=C([H])C([H])=C3N([H])C=2C([H])([H])N([H])C([H])([H])C2C([H])=C([H])C3C([H])=C([H])N(C([H])([H])C4=C([H])N(C([H])([H])[H])C([H])=N4)C=3C=2[H])N1[H])O[H]
• Formula: C₃₁H₂₈N₆O₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.