BDTX-189

• Catalog Number: orb757593
• Category: Small Molecules
• Description: BDTX-189 is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, includes EGFR/HER2 exon 20 insertion mutants. BDTX-189 shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity.
• CAS Number: [2414572-47-5]
• MW: 561.03
• SMILES: C=CC(NC1=CC2=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)N=CN=C2C=C1OCCN5CCOCC5)=O
• Formula: C₂₉H₂₉ClN₆O₄
• Note: For research use only
• Expiration Date: 12 months from date of receipt.