AZD6244

• Catalog Number: orb1713663
• Category: Small Molecules
• Description: ERK kinase inhibitor
• CAS Number: 606143-52-6
• Form/Appearance: White to off-white solid
• Purity: ≥98%
• MW: 457.7
• SMILES: CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
• Formula: C₁₇H₁₅BrClFN₄O₃
• Hazard Information: Classification: Serious Eye Damage/Eye Irritation, Category 1 Skin Sensitization, Category 1 Toxic To Reproduction, Category 2 Target Organ Systemic Toxicity (repeated exposure), Category 2 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H318: Causes serious eye damage. H317: May cause an allergic skin reaction. H361: Suspected of damaging fertility or the unborn child. H373: May cause damage to {Liver, gastrointestinal tract and other major organs} through prolonged or repeated exposure. Precautionary statements: P280: Wear {protective gloves/protective clothing/eye protection/face protection}. P261: Avoid breathing {dust/fume/gas/mist/vapours/spray}. P272: Contaminated work clothing should not be allowed out of the workplace. P362+364: Take off contaminated clothing and wash it before reuse. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P260: Do not breathe {dust/fume/gas/mist/vapours/spray}. P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310: Immediately call a {POISON CENTER/doctor/...}. P302+352: IF ON SKIN: Wash with plenty of soap and water. P333+313: If skin irritation or rash occurs, seek medical advice/attention. P308+313: IF exposed or concerned: Get medical attentiodvice. P314: Get medical attentiodvice if you feel unwell.
• Solubility (25°C): Soluble in DMSO (92 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C)
• Source: Synthetic
• Storage: -20°C
• Alternative names: Selumetinib, AZD6244, 6-(4-bromo-2-chloroanilino)-
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Chemical structure of AZD6244, a ERK kinase inhibitor. CAS #: 606143-52-6. Molecular Formula: C17H15BrClFN4O3. Molecular Weight: 457.7 g/mol.