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Catalog Number | orb385982 |
---|---|
Category | Antibodies |
Description | Recognizes a protein of 39-45kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors. |
Species/Host | Mouse |
Clonality | Monoclonal |
Clone Number | AURKB/1521 |
Tested applications | WB |
Reactivity | Human |
Isotype | Mouse IgG1, kappa |
Immunogen | Amino acids 89-251 were used as the immunogen for this Aurora B antibody. |
Dilution range | Western blot: 0.5-1ug/ml |
Purity | Protein G affinity |
Conjugation | Unconjugated |
Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
Hazard Information | This Aurora B antibody is available for research use only. |
Entrez | 9212 |
UniProt ID | Q96GD4 |
Storage | Store the Aurora B antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide). |
Buffer/Preservatives | 0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced) and 0.05% sodium azide |
Note | For research use only |
Application notes | Optimal dilution of the Aurora B antibody should be determined by the researcher. |
Expiration Date | 12 months from date of receipt. |
Western blot testing of 1) a partial recombinant protein and 2) human liver lysate with Aurora B antibody (clone AURKB/1521). Predicted molecular weight: 39-45 kDa
SDS-PAGE Analysis of Purified, BSA-Free Aurora B Antibody (clone AURKB/1521). Confirmation of Integrity and Purity of the Antibody.
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