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Catalog Number | orb1140485 |
---|---|
Category | Proteins |
Description | CXCR4 allosteric agonist; Peptides. |
CAS Number | 1337878-62-2 |
N-terminal palmitoyl. | |
Pal-Met-Gly-Tyr-Gln-Lys-Lys-Leu-Arg-Ser-Met-Thr-Asp-Lys-Tyr-Arg-Leu-OH | |
Chemokine receptors | |
Form/Appearance | Freeze dried solid |
Purity | > 95% by hplc |
MW | 2256.82 Da |
Formula | C104H178N26O25S2 |
Solubility (25°C) | Soluble to 1 mg/ml in water |
Protein Sequence | Pal-MGYQKKLRSMTDKYRL |
Storage | Store dry, frozen and in the dark |
Alternative names | , 1337878-62-2, ATI 2341, MGYQKKLRSMTDKYRL, Pal-MG Read more... |
Background | ATI 2341 is a pepducin targeting the C-X-C chemokine receptor type 4 (CXCR) at which it is an allosteric agonist with an EC50 of 194 nM. ATI 2341 functions as a biased ligand, favouring Gαi activation over Gα13. In contrast to the the natural CXCR4 agonist, stromal cell-derived factor-1α, ATI 2341 does not promote β-arrestin recruitment. ATI 2341 induces chemotaxis in CXCR4 expressing cells in vitro and acts as a functional antagonist to mobilise polymorphonuclear neutrophils and hematopoietic stem and progenitor cells from bone marrow niche in both mice and non-human primates. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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