Aslan003

• Catalog Number: orb746502
• Category: Small Molecules
• Description: ASLAN003 is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. ASLAN003 inhibits protein synthesis via activation of AP-1 transcription factors. ASLAN003 induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice.
• CAS Number: [1035688-66-4]
• MW: 356.3228717
• SMILES: FC1C([H])=C(C([H])=C(C=1N([H])C1=C(C(=O)O[H])C([H])=C([H])C([H])=N1)F)C1C([H])=C([H])C([H])=C(C=1[H])OC([H])([H])[H]
• Formula: C₁₉H₁₄F₂N₂O₃
• Note: For research use only
• Expiration Date: 12 months from date of receipt.