AS601245

• Catalog Number: orb611481
• Category: Small Molecules
• Description: AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties.
• CAS Number: [345987-15-7]
• MW: 372.4462
• SMILES: C(C1C=CN=C(NCCC2=CN=CC=C2)N=1)(C1SC2=CC=CC=C2N=1)C#N
• Formula: C₂₀H₁₆N₆S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.