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ARCC-4
Catalog Number: orb1989542
| Catalog Number | orb1989542 |
|---|---|
| Category | Small Molecules |
| Description | ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL)-recruiting AR PROTAC and outperforms enzalutamide and it is a low-nanomolar androgen receptor (AR) degrader based on PROTAC, with a DC50 of 5 nM. ARCC-4 effectively degrades clinically relevant AR mutants associated with antiandrogen therapy[1]. |
| CAS Number | 1973403-00-7 |
| Purity | 98.00% |
| MW | 1024.18 |
| SMILES | Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCCOc2ccc(cc2)-c2ccc(cc2)N2C(=S)N(C(=O)C2(C)C)c2ccc(C#N)c(c2)C(F)(F)F)C(C)(C)C)cc1 |
| Formula | C53H56F3N7O7S2 |
| Biological Activity | ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL)-recruiting AR PROTAC and outperforms enzalutamide and it is a low-nanomolar androgen receptor (AR) degrader based on PROTAC, with a DC50 of 5 nM. ARCC-4 effectively degrades clinically relevant AR mutants associated with antiandrogen therapy[1]. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
