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Catalog Number | orb1686887 |
---|---|
Category | Small Molecules |
Description | APJ receptor agonist 5 |
CAS Number | 2135514-20-2 |
Purity | 98% |
MW | 479.52 |
SMILES | C(OCC)C=1N(C(O)=C(C(=O)N2C[C@H](CC2)C3=CC=CC=C3)C(=O)N1)C4=C(OC)C=CC=C4OC |
Formula | C26H29N3O6 |
Biological Activity | APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor ( APJ ) with an EC 50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease [1]. |
Storage | Store at -20°C for 12 months. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
> 95% by HPLC | |
1533.8 Da | |
Glp-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH |
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