APJ receptor agonist 4

• Catalog Number: orb1691201
• Category: Small Molecules
• Description: APJ receptor agonist 4
• CAS Number: 2135515-67-0
• Purity: 98%
• MW: 551.02
• SMILES: CCc1cccc(CC)c1-n1c(O)c(C(=O)N2CCC(C2)c2ncc(Cl)cc2F)c(=O)nc1-c1ccn(C)n1
• Formula: C₂₈H₂₈ClFN₆O₃
• Biological Activity: APJ Receptor Agonist 4 is a potent, orally active apelin receptor (APJ) agonist, demonstrating an EC50 of 0.06 nM and a Ki of 0.07 nM. It exhibits excellent pharmacokinetic profiles in rodent heart failure (HF) models and has shown an acceptable safety profile in preclinical toxicology studies. This compound effectively improves cardiac function, making it valuable for research into HF disease.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.