API-1(NSC 177223)

• Catalog Number: orb1089904
• Category: Small Molecules
• Description: API-1 is a potent Akt inhibitor, which induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis . API-1 rapidly and potently reduced the levels of Mcl-1 primarily in API-1-senstive lung cancer cell lines. Ectopic expression of Mcl-1 protected cells from induction of apoptosis by API-1.
• CAS Number: [36707-00-3]
• MW: 337.2881
• SMILES: OCC1C(O)C(O)C(O1)N2C3C(=C(N)N=CN=3)C(=O)C(C(N)=O)=C2
• Formula: C₁₃H₁₅N₅O₆
• Note: For research use only
• Expiration Date: 12 months from date of receipt.