Apcin

• Catalog Number: orb1298832
• Category: Small Molecules
• Description: Apcin
• CAS Number: 300815-04-7
• Purity: 96.74%
• MW: 438.65
• SMILES: CC1=NC=C(N1CCOC(=O)NC(NC1=NC=CC=N1)C(Cl)(Cl)Cl)[N+]([O-])=O
• Formula: C₁₃H₁₄Cl₃N₇O₄
• Biological Activity: Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. It acts by blocking mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.