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Antifungal agent 72
Catalog Number: orb2277984
| Catalog Number | orb2277984 |
|---|---|
| Category | Small Molecules |
| Description | Antifungal agent 72 (Compound B8) demonstrates potent activity by inhibiting the efflux pump function and downregulating resistance-associated genes via disruption of the Pdr1-KIX interaction (K i : 11.7 μM). It exhibits efficacy against Fluconazole-resistant strains, evidenced by a MIC of 63 ng/mL, and displays synergistic effects when combined with Fluconazole. This compound is particularly useful for researching C. glabrata infections [1]. |
| Purity | 98.00% |
| MW | 274.34 |
| Formula | C13H14N4OS |
| Biological Activity | Antifungal agent 72 (Compound B8) demonstrates potent activity by inhibiting the efflux pump function and downregulating resistance-associated genes via disruption of the Pdr1-KIX interaction (K i : 11.7 μM). It exhibits efficacy against Fluconazole-resistant strains, evidenced by a MIC of 63 ng/mL, and displays synergistic effects when combined with Fluconazole. This compound is particularly useful for researching C. glabrata infections [1]. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
