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Anti-Notch1 Monoclonal Antibody
Catalog Number: orb546994
| Catalog Number | orb546994 |
|---|---|
| Category | Antibodies |
| Description | Anti-Notch1 Monoclonal Antibody. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. |
| Species/Host | Rabbit |
| Clonality | Monoclonal |
| Clone Number | BGA-14 |
| Tested applications | FC, ICC, IF, IHC, WB |
| Reactivity | Human, Mouse, Rat |
| Isotype | Rabbit IgG |
| Immunogen | A synthesized peptide derived from human Notch1 Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. |
| Antibody Type | Primary Antibody |
| Concentration | Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
| Form/Appearance | Liquid |
| Conjugation | Unconjugated |
| MW | 110 kDa |
| UniProt ID | P46531 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Alternative names | Signal transducer and activator of transcription 3 Read more... |
| Note | For research use only |
| Application notes | WB 1:500-1:3000IHC 1:50-1:200ICC/IF 1:100-1:500FC 1:200-1:500. Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL |
| Expiration Date | 12 months from date of receipt. |
WB analysis of NOTCH1 expression in (1) HEK293 Cell; (2) K562 Cell; (3) U20S Cell; (4) Jurkat Cell; (5) HeLa Cell; (6) THP-1 Cell; (7) CACO-2 Cell; (8) rat brain tissue; (9) PC-12 Cell; (10) mouse lung tissue; (11) mouse brain tissue tissue.
Immunofluorescent analysis of HeLa cells, using Notch1 Antibody.
Immunohistochemical analysis of paraffin-embedded human liver, using Notch1 Antibody.
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