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Anti-inflammatory agent 55
Catalog Number: orb1944213
| Catalog Number | orb1944213 |
|---|---|
| Category | Small Molecules |
| Description | Compound 9j (anti-inflammatory agent 55), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression of iNOS, TNF-α, IL-6, and IL-1β. It notably suppresses LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 of 0.8 μM and demonstrates anti-inflammatory effects in vivo using a mouse auricular edema model [1]. |
| CAS Number | 2924156-51-2 |
| Purity | 98.00% |
| MW | 373.32 |
| SMILES | O=[N+](C1=CC=C(O1)/C=C/C(NCCN2C3=CC=C(OC)C=C3OC2=O)=O)[O-] |
| Formula | C17H15N3O7 |
| Biological Activity | Compound 9j (anti-inflammatory agent 55), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression of iNOS, TNF-α, IL-6, and IL-1β. It notably suppresses LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 of 0.8 μM and demonstrates anti-inflammatory effects in vivo using a mouse auricular edema model [1]. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
